B→MBody to MoleculeMultiscale medical explorer
Molecular PhysiologyPathwaysReferenceDisease Lab3D HemodynamicsAnatomy AtlasConnecting to HRAHuman Reference Atlas

Anatomy is a nested system

Trace function from the whole body to a single molecule.

Select a biological pathway, move through four scales, and connect physical architecture to physiology and disease.

02

Move through scale

Organ
Structure
Cell
Molecule
CentimetersSkin
OrganCentimeters

Skin

A layered organ composed of epidermis, dermis, adnexal structures, vessels, nerves, and immune cells.

01 Architecture
Its avascular epithelium sits on a vascular connective-tissue dermis and continually renews from basal progenitors.
02 Physiologic role
Creates a mechanical, chemical, immunologic, and water-loss barrier between the body and environment.
03 Clinical connection
Disease can arise at any scale, from inherited cytoskeletal defects to autoimmune disruption of cell adhesion.
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03

Build the mechanism

  1. 01

    Mechanical force reaches the skin surface

  2. 02

    Epidermal junctions distribute the load

  3. 03

    Keratinocytes transmit force through intermediate filaments

  4. 04

    KRT5/KRT14 prevent basal-cell rupture

Interactive anatomy laboratory

Inspect the organ. Select the structures. Build the model.

This workbench loads the current Human Reference Atlas model, exposes each named mesh, and converts selected structures into a size-normalized STL.

SkinHRA reference model
No 3D reference is availableChoose another pathway or retry when HRA reconnects.

Drag to rotate · scroll to zoom · right-drag to pan · click a structure to identify it

Retrieval checkpoint

Can you reason back up the pathway?

Use the structural level in the stem to identify the most direct molecular consequence.

Question · Skin

A patient develops blisters after minor friction. Cleavage occurs within basal keratinocytes. Which molecular pair is most directly implicated?